Orthopaedic manifestations of Beckwith- Wiedemann syndrome: a case report

Abstract

Beckwith-Wiedemann syndrome (BWS) is a genetic/epigenetic disorder with overgrowth and cancer predisposition, presenting with symptoms like macroglossia, abdominal wall de- fects, and limb length discrepancy (LLD). This case report details a 4-year-old female with BWS and a 3 cm LLD, treated with epiphysiodesis using eight-plates in her left femur and tibia. After two years, the plates were removed, achieving equal limb length. The report highlights effective surgical intervention for moderate LLD in BWS, emphasizing the impor- tance of early diagnosis and comprehensive orthopedic management, applying general LLD treatment principles to patients with Beckwith-Wiedemann syndrome.