Retroperitoneal primary dedifferentiated liposarcoma with pancreatic involvement and multiple metastasis in soft tissue, in the context of lipomatosis: a case report

Abstract

Lipomatosis is a diffuse overgrowth of mature adipose tissue. Point mutations in mitochondrial genes have been implicated in its pathogenesis, which increase oxidative stress. Nine cases of sarcoma associated with lipomatosis have been reported to date, of which only one was a dedifferentiated liposarcoma. We report a case of retroperitoneal primary dedifferentiated liposarcoma with pancreatic involvement and multiple metastases in soft tissue, in the context of lipomatosis. Expression of 4-hydroxy-2-nonenal and 8-hydroxy-2’-deoxyguanosine as markers of oxidative stress increased in sarcoma cells invading the pancreas. This case indicates the potential for the generation of dedifferentiated liposarcoma in lipomatosis via oxidative stress and underscores the necessity for follow-up of patients with lipomatosis.