Conservative versus Surgical Treatment of Spondylodiscitis

  • Aristeidis Koutsopoulos 3rd Department of Orthopaedic Surgery NKUA, KAT Hospital
  • Ioannis S Benetos 3rd Department of Orthopaedic Surgery, University of Athens, KAT Hospital, Athens, Greece
  • Ioannis Vlamis 3rd Department of Orthopaedic Surgery, University of Athens, KAT Hospital, Athens, Greece
  • Spyridon G Pneumaticos 3rd Department of Orthopaedic Surgery, University of Athens, KAT Hospital, Athens, Greece
Keywords: spondylodiscitis; vertebral osteomyelitis; spinal infection;treatment; management

Abstract

Early diagnosis and aggressive initial treatment are essential for a satisfactory outcome of patients with spondylodiscitis. However, management strategies are still controversial. Aiming to compare the results of conservative and surgical treatment of patients with spondylodiscitis, a review of the current literature was conducted by using the online Pubmed database and the following keywords: ("treatment" OR "management" OR "therapy") AND ("vertebral osteomyelitis" OR "spondylodiscitis" OR "spinal infection" OR "discitis"). The search included only comparative prospective or retrospective studies, comparing conservative versus surgical management, in terms of outcome and complications. Initially, 407 studies were identified after a primary search on the online Pubmed database. Finally, 14 studies were included in the review (12 retrospective and 2 prospective studies). In conclusion, the initial treatment of spondylodiscitis should be conservative with bed rest, bracing and proper antibiotic treatment lasting for at least 8 weeks. However, in cases of neurological deficit, abscess formation, deformities and failure of conservative management, surgical treatment is required. Although conservative treatment is associated with a higher rate of chronic back pain and long-term deformities, it is also associated with a lower mortality rate in comparison to surgical management. Perioperative complications still remain an issue in surgically treated patients; however, patients’ satisfaction and quality of life are higher compared to those of conservatively treated patients, indicating that treatment of spondylodiscitis should be individualized taking into consideration patients’ clinical presentation, imaging studies and the virulence of the responsible pathogen.

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References

Skaf GS, Domloj NT, Fehlings MG, et al. Pyogenic spondylodiscitis: an overview. J Infect Public Health. 2010;3(1):5-16.

Asamoto S, Doi H, Kobayashi N, Endoh T et al. Spondylodiscitis: diagnosis and treatment. Surg Neurol. 2005;64(2):103-08.

Cottle L, Riordan T. Infectious spondylodiscitis. J Infect. 2008;56(6):401-12.

Gentile L, Benazzo F, De Rosa et al. A systematic review: characteristics, complications and treatment of spondylodiscitis. Eur Rev Med Pharmacol Sci. 2019;23(2 Suppl):117-28.

Gouliouris T, Aliyu SH, Brown NM. Spondylodiscitis: update on diagnosis and management. J Antimicrob Chemother. 2010;65 (Suppl 3:iii):11-24.

Zarghooni K, Röllinghoff M, Sobottke R, Eysel P. Treatment of spondylodiscitis. Int Orthop. 2012;36(2):405-11.

Guerado E, Cerván AM. Surgical treatment of spondylodiscitis. An update. Int Orthop. 2012 Feb;36(2):413-20.

Nickerson EK, Sinha R. Vertebral osteomyelitis in adults: an update. Br Med Bull. 2016 Mar;117(1):121-38.

Karadimas EJ, Bunger C, Lindblad BE et al. Spondylodiscitis. A retrospective study of 163 patients. Acta Orthop. 2008;79(5):650-59.

Valancius K, Hansen ES, Høy K et al. Failure modes in conservative and surgical management of infectious spondylodiscitis. Eur Spine J. 2013;22(8):1837-44.

Nasto LA, Colangelo D, Mazzotta V et al. Is posterior percutaneous screw-rod instrumentation a safe and effective alternative approach to TLSO rigid bracing for single-level pyogenic spondylodiscitis? Results of a retrospective cohort analysis. Spine J. 2014;14(7):1139-46.

Wirtz DC, Genius I, Wildberger JE et al. Diagnostic and therapeutic management of lumbar and thoracic spondylodiscitis--an evaluation of 59 cases. Arch Orthop Trauma Surg. 2000;120(5-6):245-51.

Alas H, Fernando H, Baker JF et al. Comparative outcomes of operative relative to medical management of spondylodiscitis accounting for frailty status at presentation. J Clin Neurosci. 2020;75:134-138.

Waheed G, Soliman MAR, Ali AM et al. Spontaneous spondylodiscitis: review, incidence, management, and clinical outcome in 44 patients. Neurosurg Focus. 2019;46(1):E10.

Behmanesh B, Gessler F, Duetzmann S et al. Quality of Life Following Surgical and Conservative Therapy of Pyogenic Spinal Infection: A Study of Long-term Outcome in 210 Patients. J Neurol Surg A Cent Eur Neurosurg. 2021 Mar 9.

Woertgen C, Rothoerl RD, Englert C et al. Pyogenic spinal infections and outcome according to the 36-item short form health survey. J Neurosurg Spine. 2006;4(6):441-46.

Canouï E, Zarrouk V, Canouï-Poitrine F et al. Surgery is safe and effective when indicated in the acute phase of hematogenous pyogenic vertebral osteomyelitis. Infect Dis (Lond). 2019;51(4):268-76.

Hadjipavlou AG, Mader JT, Necessary JT et al. Hematogenous pyogenic spinal infections and their surgical management. Spine (Phila Pa 1976). 2000;25(13):1668-79.

Park KH, Chong YP, Kim SH et al. Clinical characteristics and therapeutic outcomes of hematogenous vertebral osteomyelitis caused by methicillin-resistant Staphylococcus aureus. J Infect. 2013;67(6):556-64.

Colmenero JD, Jiménez-Mejías ME, Sánchez-Lora FJ et al. Pyogenic, tuberculous, and brucellar vertebral osteomyelitis: a descriptive and comparative study of 219 cases. Ann Rheum Dis. 1997;56(12):709-15.

Sobottke R, Zarghooni K, Krengel M et al. Treatment of spondylodiscitis in human immunodeficiency virus-infected patients: a comparison of conservative and operative therapy. Spine (Phila Pa 1976). 2009;34(13):E452-58.

Sobottke R, Röllinghoff M, Zarghooni K et al. Spondylodiscitis in the elderly patient: clinical mid-term results and quality of life. Arch Orthop Trauma Surg. 2010;130(9):1083-91.

Published
2023-04-06