Spinal Surgery in Patients with Parkinson’s Disease

  • George Sapkas Professor of Orthopaedics Orthopaedic Department Metropolitan Hospital, Neo Faliron – Athens – Greece
  • Stamatios Papadakis Director of the 2nd Orthopaedic Department K.A.T. Hospital, Athens – Greece
  • Michael Papadakis Orthopaedic Surgeon Orthopaedic Department Metropolitan Hospital, Neo Faliron-Athens-Greece
Keywords: Parkinson Disease; Spinal Surgery; Complications in Parkinson Disease Short/running Title: Post-operate Spinal Complications


Parkinson’s Disease (PD) is a degenerative disorder of the central nervous system. Recent advances in the treatment of PD have improved the life expectancy and quality of life of patients. Spinal surgery improves deformities of the spine in these patients. Moreover, a lot of studies have shown that operative treatment of various diseases of the spine in PD patients is associated with a large percentage of post-operative complications, that make a surgery revision necessary.

The purpose of the present review article is to assess the number and type of complications of spine surgery in PD patients and determine whether the presence of PD predisposes patients to a higher rate of such complications


Download data is not yet available.


1. Von Campenhausen S, Bornschein B, Wick R, Botzelf K, Sampaiod C, Poewee W, Oertelb W, Siebertg U, Bergerc K, Dode R. Prevalence and incidence of Parkinson’s Disease in Europe.Eur Neuropharmacol.2005;15:473-490 https://doi.org/10.1016/j.euroneuro.2005.04.007
2. Doherty KM, Van de Warrenburg BP, Peralta MC, Silveira-Moriyama L, Azulay JP, Gershanik O, Bloem BR. Postural deformities in Parkinson’s disease. Lancet Neurol. 2011;10:538-549.doi:10.1016/S1474-3. 3.
3. Vasserman N. Parkinson’s disease and osteoporosis. Joint Bone Spine.2005;72:484-488. https//doi.org/10.1016/j.bspin.2004.04.012. 4422(11)70067
4. Invernizzi M, Carda S, Viscontini GS, Cisari C. Osteoporosis in Parkinson’s disease. Parkisonism RTelative Disorder. 2009;15:
5. Schabitz WR, Glatz K, Schuhan C, Berger C, Schwaninger M, Hartmann M, Goebel HH, Meinck HM. Severe forward flexion of the trunk in Parkinson’s disease focal myopathy of the paraspinal muscles mimicking camptocormia. Mov.Disord.2003;18;408414.346.https://doi.rg/10.1016/j. parkeldis.2009.02.009.
6. Upadhyyaha CD, Starr PA, Mummaneni PV. Spinal deformity and Parkinson disease a treatment algorithm. Neurosurg. FGocus.2010;28:1-7. https://doi.org/10.3171/2010.1.Focus09288. https://doi.org/10.1002/mds.10385.
7. Babat LB, McLain RF, Bingaman W, Kalfas I, Young P, Rufo-Smith C. Spinal surgery in patients with Parkinson’s disease construct failure and progressive deformity. Spine (Phila Pa 1976)2004;29:2006-2012. Doi:10.1097/01.brs.0000138306.02425.21.
8. Nakashima H, Yukawa Y, Ito K, Machino M, Ishiguro N, Kato F. Combined posteroanterior surgery for osteoporotic delayed vertebral fracture and neural deficit in patients with Parkinson’s disease. Nagoya J Med Sci.2014 Aug; 76(3-4):307-314.
9. Moon SH, Lee HM, Chun HJ, Kang MS, Kim HS, Park JO, Chong HS, Sohn JS. Surgical outcome of lumbar fusion surgery in patients with Parkinson disease. J. Spinal Disorder Tech. 2011;25:351-5.
10. Benatru I, Vaugoyeau M, Azulay JP. Postural disorders in Parkinson’s disease.Neurophysiol Clin.2008;38:459-465.doi.10.1016 / j. neucli. 2008.07.006.
11. Sapkas G, Lykomitros V, Soultanis K, Papadopoulos EC, Papadakis M. Spinal Surgery in patients with Parkinson’s Disease. Unsatisfactory results, failure and disappointment. Open Orthop J 2014;8:264-267. Doi.10.2174/1874325001408010264.
12. Kaspar S, Riley L, Cohen D. Spine surgery in Parkinson’s. Journal of Bone and Joint Surgery.2005-87:292-298.
13. Puvanesarajah V, Jain A, Qureshi R, Carstensen E, Tyger R, Hassanzadeh H. Elective thoracolumbar spine fusion surgery in patients with Parkinson disease. World Neurosurg.2016;913.
14. Koller H, Acosta F, Zenner J, Ferraris L, Hitzl W, Meier O, Ondra S, Koski T, Schmidt R. Spinal surgery in patients with Parkinson’s disease experiences with the challenges posed by sagittal imbalance and the Parkinson’s spine. Eur Spine J.2010;19:1785-1794. Doi 10.1007/s00586-010-1405-y. 6:267-231. https://doi.org/10.1016/j.wneu.2016.09.014.
15. Bourghli A, Guerin P, Vital JM, Aurouer N, Luc S, Olivier Gille O, Vincent Pointillart V, Obeid I. Posterior spinal gusion from T2 to the sacrum for the management of major deformities in patients with Parkinson disease: A retrospective review with analysis of complications. J Spinal Disord Tech. 2012;25:53-60. Doi: 10.1097/bsd.0b013e3182496670.
16. Peek AC, Quinn N, Casey AT, Etherington G. Thoracolumbar spinal fixation for camptocormia in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2009;80:1275-8. http://dx.doi.org/10.1136/jnnp.2008.152736
17. Scenama C, Mangone G, Bonaccorsi R, Pascal-Moussellard H. Functional results and patient satisfaction
18. Torsney KM, Noyve AJ, Bestwick J, Dobson R, Lees A. Bone health in Parkinson’s disease: a systematic review and meta-analysis. J.Neurol Neurosurgery Psychiatry. 2014;85:1159-1166. https://dx.doi.org/10.1136/jnnp-2013-307307
19. Hoehn MM, Yahr M. Parkinsonism: onset, progression and mortality. Neurology, 1967;17:427-442.doi:10-1212/wnl.17.5.427
20. Schroeder JE, Hughes A, Sama A, Weinstein J, Kaplan L, Cammisa F, Girardi F. Lumbar spine surgery in patients with Parkinson disease. J Bone Joint Surg Am. 2015;97:1661-1666.doi:10-2106/JBJS.N. 01049.
21. Bouyer B, Scenama C, Roussouly P, Laouissat F, Obeid I, Boissiere L, Parent FH, Schuller S, Steib JP, Pascal-Moussellard H, Guigui P, Wolff S, Guillaume R. Evolution and complications after surgery for spine defortmation in patients with Parkinson’s disease. Orthop Traumatol Surg Res, 2017;103:517-522. https://doi.org/10.1016/j.otsr.2016.12.04.
22. Sarkiss CA, Fogg GA, Sjovrlj B, Cho SK, Caridi JM. To operate or not A literature review of surgical outcomes in 95 patients with Parkinson’s disease undergoing spine surgery. Clin NEUROL Neurosurg 2015:134:122-125. https://doi.org/10-1016/j.clineuro.2015.04.022.
23. Galbusera F, Tito B, Stucovitz E, Martini C, Ismael Aguirre MF, Berjano P, Lamartina C. Surgical treatment of spinal disorders in Parkinson disease. European Spine Journal. 2018;27:101-108.
24. Gerlach OH, Winogrodszka A, Weber WE. Clinical problems in the hospitalized Parkinson’s disease patient systematic review. Mov.Disord. 2011;26:197-208.doi:10.1002/mds.23449.
25. Zuckerman LM. Parkinson’s disease and the Orthopaedic patient. J Am Acad Orthop.Surg. 2009;17:48-55. Doi: 10-5435/00124635-200901000-00007.
26. Baker J, McClelland S, Robert H, Bess S. Management of Spinal Conditions in patients with Parkinson’s disease. Journal of the Americal Academy of Orthopaedic Surgeons. 2017;25:157-165.doi: 10.5435/JAAOS-D-16-00627.
27. Gdynia HJ, Sperfeld AD, Unrath A, Ludolph A, Sabolek M, Storch A, Kassubeket J. Histopathological analysis of skeletal muscle in patients with Parkinson’s disease and dropped head’/bend’ spine syndrome. Parkinsonism Relat Disord 2009;15:633-639. Doi.10.1016/j.parkeldis.2009.06.003
28. Wadia PM, Tan G, Munhoz RP, Fox S, Lewis S, Lang A. Surgical correction of kyphosis in patients with camptocormia due to Parkinson’s disease a retrospective evaluation. J. Neurol Neurosurg Psychiatry 2011;82:364-368. https://dx.doi.org/10.1136/jnnp.2009.176198.