The use of botulinum toxin in the treatment of neurogenic bladder following spinal cord injury
Spinal cord injury patients suffer from neurogenic lower urinary tract dysfunction, associated with symptoms of urinary incontinence (UI), urgency and frequency, which may affect upper urinary tract function and has a negative impact on health-related quality of life.
Botulinum toxin is a neurotoxin derived from the bacterium Clostridium botulinum. Dykstra et al, in 1988, first injected 100 BoNT-A units into the external urethral sphincter to treat patients with spinal cord injury.
The aim of this study is to search in the literature about the effectiveness, safety and side effects of botulinum toxinin treatment of neurogenic bladder (NB) due tospinal cord injuries (SCI)
Botulinum toxin is an effective and safe option for the management of neurogenic bladder in patients who have an inadequate response to, or are intolerant of, oral medication. In SCI patients with neurogenic detrusor overactivity (NDO), botulinum toxin injection significantly decreased UI and detrusor pressure, thus increasing bladder capacity and quality of life.
Mark Sanford. Botulinum toxin A (Botox): A Review of its Use in the Treatment of Urinary Incontinence in Patients with Multiple Sclerosis or Subcervical Spinal Cord Injury. Drugs DOI10.1007/s40265-014-0271-z ,2017
Jean-Jacques Wyndaele. The management of neurogenic lower urinary tract dysfunction after spinal cord injury. NATURE REVIEWS | UROLOGY VOLUME 13 | DECEMBER 2016 | 705
Po-Fan Hsieh, Hung-Chieh Chiu, Kuan-Chiehof Overactive Bladder. Toxins 2016, 8, 59; doi:10.3390/toxins8030059
X.-T. Ge, Y.-F. Li, Q. Wang, et al. Effect of on Detrusor Hyperreflexia in Spinal Cord Injured Patients. Drug Res 2015; 65: 327–331
Chiara Traini, Maria Giuliana Vannucchi. The Overactivity: The Double-Face of the Neurotoxin. Toxins 2019, 11, 614; doi:10.3390/toxins11110614
David Eldred-Evans, Prokar Dasgupta. Use of botulinum toxin for voiding dysfunction2017 Apr; 6(2): 234–251. PMID: 28540231 1.
Michael Kennelly, Roger Dmochowski, Heinrich Schulte-Baukloh et al. Efficacy and Safety of botulinum toxin A Therapy are Sustained Over 4 Years of Treatment in Patients With Neurogenic Detrusor Overactivity: Final Results of a Long-Term Extension Study. Neurourology and Urodynamics Published online in Wiley Online Library (wileyonlinelibrary.com).DOI 10.1002/nau.22934 2015 Wiley Periodicals, Inc.
Francisco Cruz and Victor Nitti. Chapter 5: Clinical Data in Neurogenic Detrusor Overactivity (NDO) and Overactive Bladder (OAB) .Neurourology and Urodynamics 33:S26–S31 (2014) Published online in Wiley Online Library (wileyonlinelibrary.com) DOI 10.1002/nau.22630
Rui Zhang, Yongteng Xu, Shengping Yang, et al. Botulinum toxin A for neurogenic detrusor overactivity and dose differences: a systematic review .REVIEW ARTICLE Vol. 41 (2): 207-219, March - April, 2015
Sheng-Mou Hsiao, Ho-Hsiung Lin, Hann-Chorng Kuo. Factors Associated with Therapeutic Efficacy of Intravesical botulinum toxin A Injection for Overactive Bladder Syndrome PLOS ONE | DOI:10.1371/journal.pone.0147137 January 29, 2016
Sheng-Fu Chen, Chia-Hwei Chang, Hann-Chorng Kuo. Clinical Efficacy and Changes of Urothelial Dysfunction after Repeated Detrusor Botulinum Toxin A Injections in Chronic Spinal Cord-Injured Bladder.2016 Jun; 8(6): 164 PMID: 27249005
JM Soler, JG Previnaire, N Hadiji. Predictors of outcome for urethral injection of botulinum toxin to treat detrusor sphincter dyssynergia in men with spinal cord injury. Spinal Cord (2016) 54, 452–456
David C. Moore, Joshua A. Cohn, Roger R. Dmochowski .Use of Botulinum Toxin A in the Treatment of Lower Urinary Tract Disorders: A Review of the Literature. 2016 Apr; 8(4): 88.Published online 2016Mar 23. doi: 10.3390/toxins8040088PMID: 27023601
Tao Cheng, Weibing Shuang, Dong-dong Jia et al. Efficacy and Safety of botulinum toxin A in Patients with Neurogenic Detrusor Overactivity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 2016; 11(7):e0159307. Published online 2016 Jul 27. doi: 10.1371/journal.pone. 0159307PMCID: PMC4963110
Duthie JB, Vincent M, HerbisonGP et al. Botulinum toxin injections for adults with overactive bladder syndrome (Review). The Cochrane Collaboration. Published by JohnWiley & Sons, Ltd. The Cochrane Library 2011, Issue http://www.thecochranelibrary.com
Hejia Yuan, Yuanshan Cui, JitaoWu et al. Efficacy and Adverse Events Associated With Use of OnabotulinumtoxinA for Treatment of Neurogenic Detrusor Overactivity: A Meta-Analysis. 1Int Neurourol J 2017;21:53-61 https://doi.org/10.5213/inj.1732646.323 pISSN 2093-4777 · eISSN 2093-6931
Hui-Yun Gu, Ju-KunSong,Wen-Jun Zhang et al. A systematic review and meta-analysis of effectiveness and safety of therapy for overactive bladder using botulinum toxin A at different dosages. Published online 2017 Aug7. doi: 10.18632/oncotarget.20056. 2017 Oct 27; 8(52): 90338–90350 PMID: 29163833
Jianshu Ni, Xiaohu Wang, Nailong Cao, et al. Is repeat Botulinum Toxin A injection valuable for neurogenic detrusor overactivity- A systematic review and meta-analysis. Neurourology and Urodynamics. 2017;1–12. 1. wileyonlinelibrary.com/journal/nau
Aaron Kaviani, Rose Khavari. Disease-Specific Outcomes of Botulinum Toxin Injections for Neurogenic Detrusor Overactivity. Urol Clin N Am 44 (2017) 463–474 http://dx.doi.org/10.1016/j.ucl.2017.04.012
Young Sam Cho, Khae Hawn Kim. Botulinum toxin in spinal cord injury patients with neurogenic detrusor overactivity. Journal of Exercise Rehabilitation 2016;12(6):624-631.Publishedonline: December31,201DOI: https://doi.org/10. 12965 / jer. 1632874.437
Jung Ki Jo, Kyu Nam Kim, Dong Won Kim et al. The effect of onabotulinumtoxinA according to site of injection in patients with overactive bladder: a systematic review and meta analysis. World J Urol DOI 10.1007/s00345-017-2121-6 , 2017
Jeremy B. Myers, Sara M. Lenherr , John T. Stoffel,et al. The effects of augmentation cystoplasty and botulinum toxin injection on patient-reported bladder function and quality of life among individuals with spinal cord injury performing clean intermittent catheterization. Neurourology and Urodynamics. 2018;1–10 DOI: 10.1002/nau.23849
Guang-Ping Li, Xiao-Yan Wang, Yong Zhang Int. Efficacy and Safety of OnabotulinumtoxinA in Patients With Neurogenic Detrusor Overactivity Caused by Spinal Cord Injury: A Systematic Review and Meta-analysis. Neurourol J. 2018 Dec; 22(4): 275–286. 1.
Guoqing Chen, Limin Liao, Fei Zhang. Efficacy and safety of botulinum toxin a injection into urethral sphincter for underactive bladder. 2019; 19: 60. Published online 5. doi: 10.1186/s12894-019-0490-4PMID: 312776351.
Copyright (c) 2022 Acta Orthopaedica Et Traumatologica Hellenica
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.