The use of botulinum toxin in the treatment of neurogenic bladder following spinal cord injury

  • S Sivetidou
  • ME Evangelopoulos
Keywords: botulinum toxin, neurogenic bladder, overactive detrusor, spinal cord injury


Spinal cord injury patients suffer from neurogenic lower urinary tract dysfunction, associated with symptoms of urinary incontinence (UI), urgency and frequency, which may affect upper urinary tract function and has a negative impact on health-related quality of life.

Botulinum toxin is a neurotoxin derived from the bacterium Clostridium botulinum. Dykstra et al, in 1988, first injected 100 BoNT-A units into the external urethral sphincter to treat patients with spinal cord injury.

The aim of this study is to search in the literature about the effectiveness, safety and side effects of botulinum toxinin treatment of neurogenic bladder (NB) due tospinal cord injuries (SCI)

Botulinum toxin is an effective and safe option for the management of neurogenic bladder in patients who have an inadequate response to, or are intolerant of, oral medication. In SCI patients with neurogenic detrusor overactivity (NDO), botulinum toxin injection significantly decreased UI and detrusor pressure, thus increasing bladder capacity and quality of life.


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Author Biographies

S Sivetidou

MD: Consultant, Department of Physical Therapy & Rehabilitation, KAT Hospital, Athens, Greece

ME Evangelopoulos

MD, PhD: Ass. Professor, Department of Neurology, Eginition University Hospital, Athens, Greece


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