The significance of peroxisome proliferator activated receptors PPAR-γ pathway in Arthritis

  • Dimitrios Economopoulos MD, M.Sci, Ph.D, Orthopaedic Surgeon
  • Ioannis K. Triantafyllopoulos MD, MSci, Ph.D, Assistant Professor of Orthopaedics Laboratory for the Research of Musculoskeletal System, Medical School, National and Kapodestrian University of Athens, Greece
Keywords: arthritis; cartilage; peroxisome proliferator activated receptors; pathways


PPAR – γ are members of a nuclear receptors superfamily located in various parts of the human body. They are implicated in many biochemical pathways and are shown to hold a key role in adipogenesis, adipose tissue differentiation and regulation of glucose levels, while also exhibiting anti-inflammatory properties. Furthermore, numerous studies have verified their implication in the process of cell differentiation and apoptosis. Over the last decade there has been ongoing interest and continuous investigation concerning their potential role on bone metabolism and the treatment of arthritis.


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